ILUMIEN-IV investigated the application of optical coherence tomography (OCT)-guided PCI for individuals with diabetes and/or complex coronary lesions. Dr. Ziad Ali and colleagues (DeMatteis – St Francis, United States of America) aimed to determine whether this approach could lead to improved post-PCI lumen dimensions and better clinical cardiovascular outcomes compared to angiography-guided PCI in these patients.
The study revealed that OCT guidance resulted in a slightly larger minimum stent area in comparison to angiography guidance. However, there was no significant disparity in the percentage of patients experiencing target-vessel failure at the two-year mark. Consequently, ILUMIEN-IV did not demonstrate the superiority of OCT-guided PCI over angiography-guided PCI in this patient population.