Better outcomes have been demonstrated with coronary artery bypass grafting (CABG) than with percutaneous coronary intervention (PCI) in three-vessel coronary artery disease (CAD). However, the PCIs performed in these studies were guided by angiography, not fractional flow reserve (FFR) measurements. Investigators aimed to conduct a noninferiority trial to compare FFR-guided … [Read more...] about FAME 3 noninferiority trial: FFR-guided PCI vs CABG
Videos
COAPT Trial: Renal dysfunction and cardiac outcomes in heart failure
Patients with heart failure (HF) and severe secondary mitral regurgitation (MR) frequently also suffer from baseline renal disease (RD). Renal function is further impaired by HF and MR, often accelerating progression to end-stage renal disease (ESRD), necessitating a form of renal replacement therapy (RRT). For patients with MR deemed too high-risk for surgery, the … [Read more...] about COAPT Trial: Renal dysfunction and cardiac outcomes in heart failure
EMPEROR Preserved: Empagliflozin in heart failure with preserved ejection fraction
Patients with heart failure (HF) and a preserved (>40%) left ventricular ejection fraction (LVEF) have few therapeutic options. Sodium glucose cotransporter 2 inhibitors have been shown to reduce the risk of hospitalization for HF in patients with HF and a reduced LVEF. It is unknown if these drugs can provide a similar benefit for patients with HF with a preserved LVEF … [Read more...] about EMPEROR Preserved: Empagliflozin in heart failure with preserved ejection fraction
Value of real-world DOAC data on atrial fibrillation treatment
Following the approval of direct oral anticoagulants (DOACs) a number of real-world studies were initiated to look at their impact on atrial fibrillation (AF) patients seen in daily practice. Unlike randomized controlled trials, real-world studies do not have strict exclusion criteria and look include many AF patients with various comorbidities. However, there are fundamental … [Read more...] about Value of real-world DOAC data on atrial fibrillation treatment
COVID-19 and cardiac arrest, a lethal combination
Researchers compared outcomes of patients who had suffered in- and out-of-hospital cardiac arrest, before and after the onset of the COVID-19 pandemic (16 March 2020). Between 01 January and 20 July 2020, 3026 cardiac arrests were reported to the Swedish Registry for Cardiopulmonary Resuscitation. https://youtu.be/n8g-88glR-Q Of these 3026 cardiac arrests, 1946 occurred … [Read more...] about COVID-19 and cardiac arrest, a lethal combination