The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms in patients with chronic heArt faiLure) trials evaluated the effect of 10 mg empagliflozin versus placebo on exercise ability in patients with heart failure. EMPERIAL-Reduced (NCT03448419) randomized 312 patients with heart failure with reduced ejection fraction (LVEF ≤ 40%) to receive either … [Read more...] about Effect of Empagliflozin on exercise ability and symptoms in heart failure patients
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Superior Cardiac Outcomes with addition of SGLT2i to GLP-1RA
Atherosclerotic cardiovascular disease and heart failure occur more frequently in patients with type 2 diabetes mellitus. Therefore, the major goal of care of patients with type 2 diabetes is to reduce the incidence of these events. Both glucagon-like peptide agonists (GLP-1RA’s) and sodium-glucose co-transporter 2 inhibitors (SGLT2i’s) can independently improve glucose control … [Read more...] about Superior Cardiac Outcomes with addition of SGLT2i to GLP-1RA
ARTICA Trial: Research in Progress
The ARTICA (“Acute Rule out of non ST-segment elevation acute coronary syndrome in the (pre)hospital setting”) trial is being conducted at Radboud UMC in Nijmegen, the Netherlands. Dr. Cyril Camaro and his team started this randomized, 2-arm trial in March 2019 and plan to finish March 2022. The objective of the ARTICA trial is to assess cost-effectiveness and efficacy of … [Read more...] about ARTICA Trial: Research in Progress
SAMSON Trial: Role of nocebo effect in statin-associated muscle symptoms
The phenomenon of non-adherence to statin therapy is well known. Reasons for discontinuation include elevated hepatic or muscular enzymes, neurological symptoms, and muscular symptoms collectively referred to as statin-associated muscle symptoms (SAMS).1 SAMS seems to occur less frequently in randomized control trials than in observational studies. These results suggest that … [Read more...] about SAMSON Trial: Role of nocebo effect in statin-associated muscle symptoms
Thromboembolism in COVID-19 patients despite thromboprophylaxis
Cardiovascular events are frequently seen in association with coronavirus disease-2019 (COVID-19), particularly thromboembolisms. Researchers from Brigham and Women’s Hospital in Massachusetts just published results from their multicentre, observational cohort study investigating thromboembolism in patients with COVID-19 (COVID-19 Registry to Assess Frequency, Risk Factors, … [Read more...] about Thromboembolism in COVID-19 patients despite thromboprophylaxis