The phenomenon of non-adherence to statin therapy is well known. Reasons for discontinuation include elevated hepatic or muscular enzymes, neurological symptoms, and muscular symptoms collectively referred to as statin-associated muscle symptoms (SAMS).1 SAMS seems to occur less frequently in randomized control trials than in observational studies. These results suggest that … [Read more...] about SAMSON Trial: Role of nocebo effect in statin-associated muscle symptoms
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Thromboembolism in COVID-19 patients despite thromboprophylaxis
Cardiovascular events are frequently seen in association with coronavirus disease-2019 (COVID-19), particularly thromboembolisms. Researchers from Brigham and Women’s Hospital in Massachusetts just published results from their multicentre, observational cohort study investigating thromboembolism in patients with COVID-19 (COVID-19 Registry to Assess Frequency, Risk Factors, … [Read more...] about Thromboembolism in COVID-19 patients despite thromboprophylaxis
EXCEL trial: Repeat revascularization after CABG and PCI for left main disease
Repeat revascularization occurs more often following percutaneous coronary intervention (PCI) than coronary artery bypass grafting (CABG). The need for repeat revascularization is a less important clinical endpoint than death, stroke or myocardial infarction. However, it can have an impact on quality of life, risk of hospitalization and mortality. In the present study of … [Read more...] about EXCEL trial: Repeat revascularization after CABG and PCI for left main disease
iMODERN: When to treat non-culprit lesions in STEMI
The iMODERN trial (“iFR Guided Multi-vessel Revascularization During Percutaneous Coronary Intervention for Acute Myocardial Infarction.”) trial is an ongoing multinational study. This study will provide important knowledge on the best practice for the assessment and treatment of multi-vessel disease involving ST-segment elevation myocardial infarction (STEMI) patients. We … [Read more...] about iMODERN: When to treat non-culprit lesions in STEMI
COACT trial: Immediate vs delayed angiography in non-STEMI patients after cardiac arrest
Ischemic heart disease is the most frequent cause of out-of-hospital cardiac arrest, a leading cause of death in Europe and the United States. The COACT (Coronary Angiography after Cardiac Arrest) trial investigated whether immediate angiography after resuscitation from cardiac arrest would have better outcome as compared to delayed angiography in terms of overall survival at … [Read more...] about COACT trial: Immediate vs delayed angiography in non-STEMI patients after cardiac arrest